Being Indian and having eaten achaar, pickle Samosa, Kachori all my life, I did also notice black seed-like things in all of them. Yes, they added to taste and flavour but I wanted to know what if anywhere it benefits. Again like most queries, this was not fulfilled either. That was decades ago but now my curiosity regarding this black seed was revived all over again.
What I found in my extensive research was nothing less than astonishing. Whatever it is called, the scientific name for it is Nigella Sativa. The black cumin plant is native to southwestern Asia, the Mediterranean and Africa.
It has been cultivated for centuries for its aromatic and flavorful seeds that can be used as a spice or as a herbal medicine. Nigella sativa is used in too many conditions and diseases but according to me the most promising research done on it is the one connecting Nigella sativa to multi-drug resistant bacteria. In my mind, it is a big deal since these are those very so-called superbugs which are posing an enormous threat to public health and safety.
A study conducted by Jawaharlal Nehru Medical College researchers set out to determine just how potent black seed oil is against some of these superbugs and paired it against several antibiotics, such as Amoxicillin, Gatifloxacin and Tetracycline. The study uncovered that it was especially effective against multi-drug resistant strains of P. Thymoquinone: An active ingredient in black seed, researchers have been investigating TQ since the s. It is well-known for its antioxidant, anti-inflammatory and anticancer properties that have been reported to help with encephalomyelitis, diabetes, asthma and carcinogenesis.
Thymohydroquinone: Akin to thymoquinone, thymohydroquinone is one of the most potent natural acetylcholinesterase AChE inhibitors on the planet. AChE inhibitors are chemicals that stop enzyme activity, which increases the amount of time and the amount of the neurotransmitter acetylcholine remains active in the brain. To give you an idea of their usefulness, pharmaceutical-grade acetylcholinesterase inhibitors are used medicinally to treat a wide range of conditions, including:.
Thymol: The active ingredient that gives thyme essential oil its medicinal properties, thymol is a natural monoterpene that holds a number of useful qualities. For example:. Thanks to its potent phytochemicals and antioxidant capabilities, black seed oil has been shown to help naturally treat cancer. Pharmacol Res. A review on therapeutic potential of Nigella sativa: a miracle herb.
Asian Pac J Trop Biomed. Mollazadeh H, Hosseinzadeh H. The protective effect of Nigella sativa against liver injury: a review. Iran J Basic Med Sci. Cardio-protective and anti-cancer therapeutic potential of Nigella sativa. Nigella sativa: reduces the risk of various maladies. Crit Rev Food Sci Nutr. Review on molecular and therapeutic potential of thymoquinone in cancer.
Nutr Cancer. Abukhader MM. Thymoquinone in the clinical treatment of cancer: fact or fiction? Pharmacogn Rev. Black cumin Nigella sativa and its constituent thymoquinone : a review on antimicrobial effects.
Antibacterial activity of total extracts and essential oil of Nigella sativa L. Amin B, Hosseinzadeh H. Black Cumin Nigella sativa and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects.
Planta Med. Effects of intraperitoneal thymoquinone on chronic neuropathic pain in rats. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. Antitussive effect of thymoquinone, a constituent of Nigella sativa seeds, in guinea pigs. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. Int Immunopharmacol. Effect of thymoquinone, a constituent of Nigella sativa L.
Naunyn-Schmiedebergs Arch Pharmacol. Effect of Nigella sativa seed extracts on ischemia-reperfusion in rat skeletal muscle. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Cardiovascular benefits of black cumin Nigella sativa Cardiovasc Toxicol. Razavi B, Hosseinzadeh H. A review of the effects of Nigella sativa L.
J Endocrinol Invest. Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med Sci Monit. Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Effect of Nigella sativa fixed oil on ethanol toxicity in rats.
Neuroprotective effect of thymoquinone in acrylamideinduced neurotoxicity in wistar rats. A review of neuropharmacology effects of Nigella sativa and its main component, thymoquinone. Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage. Hosseinzadeh H, Montahaei R. Protective effect of Nigella sativa L. Hypolipidemic effects of Nigella sativa L. Blood pressure lowering effect of Nigella sativa L.
Effects of Nigella sativa oil on some blood parameters in type 2 diabetes mellitus patients. Asian J Chem. Acta Med Indones. Effectiveness, safety, and tolerability of powdered Nigella sativa kalonji seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial.
J Altern Complement Med. Effect of Nigella Sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol. BS Black seed Nigella sativa regulates glucose, insulin level and lipid profile in patients with type 2 diabetes. Diabetes Res Clin Pract. Effect of Nigella sativa tea in type 2-diabetic patients as regards glucose homeostasis, liver and kidney functions.
J Appl Sci Res. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol. Comparing Nigella sativa oil and fish oil in treatment of vitiligo. Iran Red Crescent Med J. The effect of Nigella sativa extract on biochemical bone markers in osteopenic postmenopausal women.
Iran J Endocrinol Metab. Effects of Nigella sativa L. Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: a double blind randomized controlled clinical trial. J Ethnopharmacol. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol.
Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. Int J Clin Pharmacol Ther. Akhtar MS, Riffat S. Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. J Pak Med Assoc. Montelukast versus Nigella sativa for management of seasonal allergic rhinitis: a single blind comparative clinical trial. Pak J Med Sci. Evaluation of topical black seed oil in the treatment of allergic rhinitis.
Antiinflamm Antiallergy Agents Med Chem. Preliminary assessment of efficacy of Nigella sativa seeds in acute lymphoblastic leukemia in local children. A case study report of acute renal failure associated with Nigella sativa in a diabetic patient. J Integr Med. Bamosa A. Nigella sativa is a safe herbal product. Ibraheim ZZ. Effect of Nigella sativa seeds and total oil on some blood parameters in female volunteers. Saudi Pharm J. Ann Dermatol Venereol.
Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects. Drug Metab Lett. Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome. Dig Liver Dis. Kim B, Feldman EL.
Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome. Exp Mol Med. Effect of Nigella sativa oil on various clinical and biochemical parameters of metabolic syndrome. Int J Diabetes Metab. Clinical efficacy of the co-administration of Turmeric and Black seeds Kalongi in metabolic syndrome - a double blind randomized controlled trial- TAK-MetS trial.
Complement Ther Med. Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women: a novel role of Nigella sativa. Therapeutic effect of Nigella sativa in patients of poor glycemic control. Asian J Pharm Clin Res. Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med. Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie diet in obese women: a randomized, double-blind controlled clinical trial.
Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial. Food Funct. Serum lipids and associated factors of dyslipidemia in the adult population in Shenzhen. Lipids Health Dis. Placebo controlled study on comparison of effects of Nigella sativa and nicotinic acid along with low fat diet and physical exercise on LDL-cholesterol and HDL-cholesterol. Pak J Med Health Sci. A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women.
J Transl Med. Protective effects of Nigella sativa on metabolic syndrome in menopausal women. Adv Pharm Bull. The mechanism by which moderate alcohol consumption influences coronary heart disease. Nutr J. The effects of Nigella sativa Kalonji on lipid profile in patients with stable coronary artery disease in Multan, Pakistan.
Pak J Nut. Effect of oral ingestion of Nigella sativa seeds on some blood parameters. Ahmad Alobaidi AH. Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: a prospective, randomized, double-blind trial.
Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Med Arch. Roufogalis B, Sekhon B. No statistically significant effects of powdered Nigella sativa kalonji seed on serum lipid levels, blood sugar, blood pressure or body weight in adults. Focus Altern Complement Ther. Ameliorative effects of Nigella sativa on dyslipidemia.
Nigella sativa black seed effects on plasma lipid concentrations in humans: a systematic review and meta-analysis of randomized placebo-controlled trials. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial.
PLoS One. In the control group, chest wheezing and asthma severity decreased on the second visit but returned to baseline on the third visit. The experimental group also reported a decrease in the use of beta-agonists, corticosteroids, and theophylline, while the control group did not. The study authors concluded that Nigella sativa may have a prophylactic effect in asthmatics and that further research is warranted.
Both in animal studies and human clinical trials, it has exerted multiple positive effects on the immune system, from inhibiting inflammation to promoting phagocytosis. With a robust body of research behind it, black seed is well positioned to gain a growing profile in the immune-health market.
August 26, Mike Straus. Nutritional Outlook , Nutritional Outlook Vol. Black Seed Acts on Cytokines to Regulate Inflammation One particularly effective immune pathway through which black seed works is the inflammatory response. Reducing Reactive Oxygen Species Protects Against Oxidative Stress Cytokine inhibition is only one of the ways in which black seed boosts the immune system. References Ashraf S et al. Posted online November 30, Glick M. Published online June 17, Shen HH et al. Published online January 6,
0コメント